|
Click to view Medline abstract from Entrez
|
| RESEARCH |
Luhtala, N. and R. Parker. (2009) LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels. Nucleic Acids Research (in press) |
| REVIEW |
Thompson, D.M. and R. Parker (2009) Stressing out over tRNA cleavage. Cell 138:215-219 |
| REVIEW |
Swisher, K.D. and R. Parker (2009) Related Mechanisms for mRNA and rRNA Quality Control. Molecular Cell 34:401-402 |
| RESEARCH |
Passos, D.O., Doma, M.K, Shoemaker, C.J., Muhlrad, D., Green, J., Weissman, J., Hollien, J. and R. Parker. (2009) Analysis of Dom34 and its function in No-Go Decay. Molecular Biology of the Cell (in press) |
| REVIEW |
Balagopal, V. and R. Parker (2009) Polysomes, P bodies and Stress granules: States and Fates of Eukaryotic mRNAs. Current Opinion in Cell Biology 21:403-408 |
| RESEARCH |
Chekulaeva,
M., Filipowicz, W. and R. Parker. (2009) Multiple independent
domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA 5:794-803 |
| RESEARCH |
Thompson,
D. and R. Parker (2009) The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. Journal
of Cell Biology 185:43-50 |
| RESEARCH |
Balagopal,
V. and R. Parker. (2009) Stm1
modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae. Genetics 181:93-103 |
| REVIEW |
Rajyaguru,
P. and R. Parker (2009) Cgh-1 and the Control of Maternal mRNAs. Trends
in Cell Biology 19:24-28 |
| REVIEW |
Passos,
D.O. and R. Parker (2008) Analysis of Cytoplasmic mRNA Decay
in Saccharomyces cerevisiae. Methods in
Enzymology 448:409-427 |
| REVIEW |
Nissan,
T. and R. Parker (2008) Analyzing P-bodies in Saccharomyces
cerevisiae. Methods in
Enzymology 448:507-520 |
RESEARCH |
Buchan,
J.R., Muhlrad, D, and R. Parker. (2008) P-bodies promote Stress
Granule assembly in Saccharomyces cerevisiae. Journal
of Cell Biology 183:441-455 |
RESEARCH |
Thompson,
D.M., Lu, C., Green, P.J. and R. Parker. (2008) tRNA
cleavage is a conserved response to oxidative stress in eukaryotes. RNA 14:2095-2103 |
RESEARCH |
Pedro-Segura,
E., Vergara, S.V., Rodríguez-Navarro, S., Parker, R.,
Thiele, D.J. and S. Puig (2008) The Cth2 are-binding protein
recruits the Dhh1 helicase to promote the decay of succinate
dehydrogenase SDH4 mRNA in response to iron deficiency. Journal
of Biological Chemistry 283:28527-28535 |
RESEARCH |
Ling,
S.H., Decker, C.J., Walsh, M.A., She, M., Parker, R. and H. Song
(2008) Crystal structure of human Edc3 and its functional implications. Molecular
and Cellular Biology 28:5965-5976 |
REVIEW |
Hilliker,
A., and R. Parker (2008) "Stressed
out? Make some modifications!" Nature Cell
Biology 10:1129-1130 |
| RESEARCH |
Nissan, T. and R. Parker. Computtional analysis of miRNA-mediated repression of translation: Implications for models of translaton initiation inhibition. RNA 14:1480-1491 |
| RESEARCH |
She, M., Decker, C., Svergun, D.I., Round, A., Chen, N., Muhlrad, D., Parker, R., and H. Song (2008) Structural basis of Dcp2 recognition and activation by Dcp1. Molecular Cell 29:337-349 |
|
Beckham, C.J. and R. Parker (2008) P Bodies, Stress Granules, and Viral Life Cycles. Cell Host & Microbe 3:206-212 |
|
Beckham, C.J., Hilliker, A., Cziko, A.-M., Noueiry, A., Ramaswami, M., and R. Parker. (2008) The DEAD-Box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies. Molecular Biology of the Cell 19:984-993 |
|
Pilkington, G., and R. Parker (2008) Pat1p contains distinct functional domains that promote P-body assembly and activation of decapping.Molecular and Cellular Biology 28:1298-1312 |
|
Buchan,
J.R. and R. Parker. (2007) The Two Faces of miRNA. Science 318:1877-1878 (Summary) (Full
Text) |
|
Doma, M.K. and R. Parker. (2007) Diversity, Principles and Consequences of RNA Quality Control in Eukaryotes. Cell 131:660-668 |
|
Decker, C.J., Teixeira, D., and R. Parker (2007) Edc3p and a QN-rich domain of Lsm4p function in P-body Assembly in Saccharomyces cerevisiae. Journal of Cell Biology 179:437-449 |
|
Beckham, C.J., Light, H.R., Nissan, T.A., Ahlquist, P., Parker, R., and A. Nouiery (2007) Interactions between Brome Mosaic Virus RNAs and Cytoplasmic Processing Bodies Journal of Virology 81:9759-9768 |
|
Brengues, M. and R. Parker. (2007) Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae. Molecular Biology of the Cell 18:2592-2602 |
|
Teixeira, D. and R. Parker. (2007) Analysis of P-body Assembly in Saccharomyces cerevisiae. Molecular Biology of the Cell 18:2274-2287 |
|
Sheth, U., and R. Parker. (2007) P-bodies and the control of mRNA translation and degradation. Molecular Cell 25:635-646 |
|
Cheng, Z., Muhlrad, D., Lim, M.K., Parker, R. and H. Song (2007) Structural and functional insights into the human Upf1 helicase core. EMBO Journal 26:253-64 |
|
Thompson, D. M., and R. Parker. (2007) Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. MCB 27:92-101 |
|
Doma, M.K., and R. Parker. (2006). Revenge of the NRD: preferential degradation of nonfunctional eukaryotic rRNA. Developmental Cell 11:757-758 |
|
Barbee, S.A., Estes, P.S., Cziko, A-M., Hillebrand, J., Luedeman, R.A., Coller, J.M., Johnson, N., Howlett, I.C., Geng, C., Ueda, R., Brand, A.H., Newbury, S.F., Wilhelm, J.E., Levine, R.B., Nakamura, A., Parker, R., and M. Ramaswami. (2006) Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies. Neuron 52:997-1009 |
|
Valencia-Sanchez, M., Liu, J., Hannon, G.J. and R. Parker. (2006) Control of translation and mRNA degradation by miRNAs and siRNAs. Genes and Development 20:515-524 |
|
Baker, K.E. and R. Parker. (2006) Conventional 3' end formation is not required for NMD substrate recognition in Saccharomyces cerevisiae RNA 12:1441-1445 |
|
Sheth, U., and R. Parker. (2006) Targeting of Aberrant mRNAs to Cytoplasmic Processing Bodies. Cell 125:1095-1109 |
|
Segal, S.P., Dunckley, T.C., and R. Parker. Sbp1p promotes tranlsational repression and mRNA decapping in Saccharomyces cereivisiae. MCB 26:5120-5130 |
|
Doma, M.K., and R. Parker. (2006) Endonucleolytic cleavage of eukaryotic mRNAs with translation elongation stalls. Nature 440:561-564 |
|
Decker, C.J. and R. Parker (2006) CAR-1 and trailer hitch: Driving mRNP granule function at the ER? Journal of Cell Biology Journal of Cell Biology 173:159-163 |
|
Beliakova-Bethell, N., Beckham, C., Giddings Jr., T.H., Winey, M., Parker, R., and S. Sandmeyer. (2006) Virus-like particles of the Ty3 retrotransposon assemble in association with P-body components. RNA 12:94-101 |
|
She, M., Decker, C.J., Chen, N., Tumati, S., Parker, R., and H. Song. (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe.Nature Structural & Molecular Biology (in press) |
|
Liu, J., Rivas, F.V., Wohlschlegel, J., Yates III, J.R., Parker, R., and G.J. Hannon. (2005) A role for the P-body component GW182 in microRNA function. Nature Cell Biology 7:1261-1266 |
|
Coller, J. and R. Parker. (2005) General Translational Repression by Activators of mRNA Decapping. Cell 122:875-886 |
|
Brengues, M., Teixeria, D. and R. Parker (2005) Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies. Science 310:486-489 Click here for access to complete article at Science |
|
Wilson, M., Meaux, S., Parker, R., and A. van Hoof. (2005). Molecular mechanisms of [PSI+] induced phenotypic variation in yeast. Proc. Natl. Acad. Sci. USA 102:10244-10249 |
|
Liu, J., Sanchez, M.A.V., Hannon, G.J., and R. Parker. (2005) MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nature Cell Biology 7:719-723 |
|
Cheng, Z., Coller, J., Parker, R., and H. Song. (2005) Crystal structure and functional analysis of DEAD box helicase Dhh1p. RNA 11:1258-1270 |
|
Tharun, S., Muhlrad, D., Chowdhury, A., and R. Parker. (2005) Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection. Genetics, 170:33-46 |
|
Teixeria, D., Sheth, U, Valencia-Sanchez, MA, Brengues, M., and R. Parker. (2005) Processing bodies require RNA for assembly and contain non-translating mRNAs. RNA 11:371-382 |
|
Muhlrad, D. and R. Parker. (2005) The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p and Not5p. EMBO 24:1033-1045 |
|
Chen, N., Walsh, M.A., Liu, Y., Parker, R., and H. Song. (2005) Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. Journal of Molecular Biology 347:707-718 |
|
Cheng, Z., Liu, Y., Wang, C., Parker R., and H. Song. (2004) Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recomination. Protein Science 13:2673-2684 |
|
Baker, K.E., Coller, J.M., and R. Parker. (2004) Yeast Apq1p affects nucleocytoplasmic mRNA transport. RNA 10:1352-1358 |
|
Kshirsagar, M., and R. Parker, (2004) Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae. Genetics 166:729-739 |
|
She, M., Decker, C.J., Sundramurthy, K., Liu, Y., Chen, N., Parker, R. and H. Song. (2004) Crystal Structure of Dcp1p and Its Functional Implications in mRNA Decapping. Nature Structural and Molecular Biology 11:249-6 |
|
Baker, K.E., and R. Parker. (2004) Nonsense-mediated mRNA decay: terminating erroneous gene expression. Current Opinion Cell Biology 16:293-9 |
|
Parker, R. and H. Song. (2004) The Enzymes and Control of Eukaryotic mRNA Turnover. Nature Structural and Molecular Biology 11:121-127 |
|
Coller, J. and R. Parker. (2004) Eukaryotic mRNA decapping. Annual Review of Biochmistry 73:861-890 |
|
Hilleren, P.J., and R. Parker. (2003) Cytoplasmic Degradation of Splice Defective pre-mRNAs and Intermediates Molecular Cell 12:1453-1465 |
|
Cao, D., and R. Parker. (2003) Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast. Cell 113:533-545 |
|
Sheth, U., and R. Parker. (2003) Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300:805-808 |
|
Schwartz, D., Decker, C.J., and R. Parker. (2003) The Enhancer of Decapping Proteins, Edc1p and Edc2p, bind RNA and stimulate activity of the decapping enzyme. RNA 9:239-251 |
|
Decker, C.J. and R. Parker (2002) mRNA decay enzymes: Decappers conserved between yeast and mammals. Proc. Natl. Acad. Sci. USA 99:12512-12514 |
|
van Hoof, A., and R. Parker. (2002) Mammalian mRNA degradation: Beginning at the end. Current Biology 12:R285-R287 |
|
Steiger, M., Carr-Schmid, A., Schwartz, D.C., Kiledjian, M., and R. Parker. (2002) Analysis of recombinant yeast decapping enzyme. RNA 9:231-238 |
|
Steiger, M., and R. Parker (2002) Analyzing mRNA Decay in Saccharomyces cerevisiae. Methods in Enzymology 351:648-660 |
|
Decker, C.J. and R. Parker (2002) mRNA decay enzymes: Decappers conserved between yeast and mammals. Proc. Natl. Acad. Sci. USA 99:12512-12514 |
|
Frischmeyer, P.A., van Hoof, A., OíDonnell K., Guerrerio A.L., R. Parker and Dietz, H.C. (2002) An mRNA Surveillance Mechanism that Eliminates Transcripts Lacking Termination Codons. Science 295: 2258-2261 |
|
van Hoof, A., Frischmeyer, P.A., Dietz, H.C., and R. Parker. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295: 2262-2264 |
|
Tucker, M., Staples, R.R., Valencia-Sanchez, M.A., Muhlrad, D., and R. Parker. (2002) Ccr4p is the catalytic sub-unit of a Ccr4/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae. EMBO Journal 21:1427-1436 |
|
Wickens, M., Bernstein, D.S., Kimble, J., and R. Parker (2002) A PUF family portrait: 3íUTR regulation as a way of life. Trends in Genetics 18:150-157 |
|
Hilleren, P., McCarthy, T., Rosbash, M., Parker, R., and Jensen, T.H. (2001) Quality control of mRNA 3í-end processing is linked to the nuclear exosome. Nature 413:538 - 542 |
|
Coller, J.M., Tucker, M., Sheth, U., Valencia-Sanchez, M.A., and R. Parker. (2001) The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA 7:1717-27 |
|
Tharun, S., and R. Parker. (2001) Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs. Molecular Cell 8:1075-83 |
|
Cao, D., and R. Parker (2001) Computational modeling of eukaryotic mRNA turnover. RNA 7:1192-1212 |
|
He, W. and R. Parker (2001) The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation. Genetics 158:1445-1455 |
|
Tucker M., Valencia-Sanchez M.A., Staples R., Chen J., Denis C.L., and R. Parker (2001) The transcription factor associated proteins Ccr4 and Caf1 are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell 104:377-386 |
|
Dunckley T., Tucker, M., and R. Parker (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157:27-37 |
|
Hilleren P., and R. Parker (2001) Defects in the mRNA export factors Rat7p, Gle1p, Mex67p and Rat8p cause hyperadenylation during 3'-end formation of nascent transcripts. RNA 7:753-64 |
|
Dunckley, T., and R. Parker (2001) Yeast mRNA Decapping Enzyme. Methods Enzymology 342:226-33 |
|
Olivas, W. and R. Parker (2000) The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast EMBO Journal 19:6602-6611 |
|
van Hoof, A., Staples, R. R., Baker, R. E. and R. Parker (2000)Function of the Ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Molecular and Cellular Biology 20:8230-8243 |
|
Schwartz, D. and R. Parker (2000) mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E. Molecular and Cellular Biology 20:7933-7942 |
|
Jacobs, J.S.J. and R. Parker (2000) Computational Identification of Cis-acting Elements Affecting Post-Transcriptional Control of Gene Expression in Saccharomyces cerevisiae. Nucleic Acids Research 28:1604-1617 |
|
Tharun, S., He, W., Mayes, A.E., Lennertz, P., Beggs, J.D., and R. Parker (2000) Yeast Sm-like proteins function in mRNA decapping and decay. Nature 404:515-518 |
|
van Hoof, A., Lennertz, P., and R. Parker. (2000) Three conserved members ofthe RNase D family have unique and overlapping functions inthe processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast. EMBO Journal 19: 1357-1365 |
|
van Hoof, A., Lennertz, P. and R. Parker (2000) Yeast Exosome Mutants Accumulate 3'-Extended Polyadenylated Forms of U4 Small Nuclear RNA and Small Nucleolar RNAs. Molecular and Cellular Biology 20:441-452 |
|
Tucker, M. and R. Parker. (2000) Mechanisms and Control of mRNA Decapping in Saccharomyces cerevisiae. Annual Review of Biochemistry 69:571-95 |
|
He, W. and Parker R. (2000) Functions of Lsm proteins in mRNA degradation and splicing. Current Opinion in Cell Biology 12:346-350 |
|
Muhlrad, D. and R. Parker (1999) Aberrant mRNAs with extended 3¹ UTRs are substrates for rapid degradation by mRNA surveillance. RNA 5:1299-1307 |
|
Muhlrad, D. and R. Parker. (1999) Recognition of Yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: Implications for the control of mRNA decapping. Molecular Biology of the Cell 10: 3971-3978 |
|
Dunckley, T. and R. Parker (1999) The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functinal MutT motif. EMBO Journal 18: 5411-5422 |
|
Schwartz, D. and R. Parker (1999) Mutations in Translation Initiation Factors lead to increased rates of deadenylation and decapping of yeast mRNAs. Molecular and Cellular Biology 19:5247-56 |
|
LaGrandeur, T. and R. Parker. (1999) The cis acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast includes the context of the translational short codon. RNA 5:420-33 |
|
Hilleren, P. and R. Parker. (1999) Mechanisms of mRNA Surveillance in Eukaryotes. Annual Review of Genetics 3:229-260 |
|
van Hoof, A. and R. Parker. (1999) The exosome: A proteasome for RNA? Cell 99:347-50 |
|
Tharun, S. and R. Parker. (1999) Analysis of mutations in the yeast mRNA decapping enzyme. Genetics 151:1273-1285 |
|
Hilleren, P. and R. Parker. (1999) mRNA Surveillance in Eukaryotes: Kinetic Proofreading of Proper Translation Termination as assessed by mRNP Domain Organization? RNA 5:711-719 |
|
He, W. and R. Parker. (1999) Analysis of mRNA Decay Pathway in S. Cerevisiae. Methods 17:3-10 |
|
LaGrandeur, T. E. and R. Parker. (1998) Isolation and Characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO Journal 17:1487-1496 |
|
Anderson, J. S. J. and R. Parker. (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO Journal 17:1497-1506 |
|
Olivas, W. M., Muhlrad, D., and Parker, R. (1997). Analysis of the yeast genome: identification of new non-coding and small ORF-containing RNAs. Nucleic Acids Res 25:4619-4625 |
|
LaGrandeur, T. E. and R. Parker. (1997) mRNA decapping activities and their biological roles. Biochemie 78:1049-1055 |
|
Caponigro, G., and Parker, R. (1996) mRNA turnover in yeast promoted by the MATalpha1 instability element. Nucleic Acids Res 24:4304-4312 |
|
Hatfield, L., Beelman, C. A., Stevens, A., and Parker, R. (1996) Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol 16:5830-5838 |
|
Anderson, J. S., and Parker, R. (1996) RNA turnover: the helicase story unwinds. Curr Biol 6:780-782 |
|
Caponigro, G., and Parker, R. (1996) Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev 60:233-249 |
|
Beelman, C. A., Stevens, A., Caponigro, G., LaGrandeur, T. E., Hatfield, L., Fortner, D., and Parker, R. (1996) An essential component of the decapping enzyme required for normal rates of mRNA decay in yeast. Nature 382:642-6 |
|
Mandart, E., and Parker, R. (1995) Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAP1 genes on polyadenylation in vivo. Mol Cell Biol 15:6979-6986 |
|
Decker C. J., and Parker, R. (1995) Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts. Curr Opin Cell Biol 7:386-392 |
|
Muhlrad D., Decker C. J., and Parker, R. (1995) Turnover mechanisms of the stable yeast PGK1 mRNA. Mol Cell Biol 15:2145-2156 |
|
Beelman, C. A. and Parker, R. (1995) Degradation of mRNA in eukaryotes. Cell 81:179-183 |
|
Caponigro, G. and Parker, R. (1995) Multiple functions of the Poly(A) binding protein in mRNA decapping and deadenylation. Genes Dev 9:2421-2432 |
|
Decker C. J., and Parker, R. (1994) Mechanisms of mRNA degradation in eukaryotes. Trends Biochem Sci 19:336-340 |
|
Beelman C. A., and Parker, R. (1994) Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem 269:9687-9692 |
|
Muhlrad, D., and Parker, R. (1994) Premature translational termination triggers mRNA decapping. Nature 340:578-581 |
|
Muhlrad, D., Decker, C. J., and Parker, R. (1994) Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5' to 3' degradation of the transcript. Genes Dev 8:855-866 |
|
Decker, C. J., and Parker, R. (1993) A turnover pathway for stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev 7:1632-1643 |
|
Parker, R. and P. Siliciano (1993) Evidence for a non-Watson Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron. Nature 361:660-662 |
|
Caponigro, G., Muhlrad, D., and Parker, R. (1993) A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons. Mol Cell Biol 13:5141-5148 |
|
Muhlrad, D., and Parker, R. (1992) Mutations affecting stability and deadenylation of the yeast MFA2 transcript. Genes Dev 6:2100-2111 |
|
Heaton, B., Decker, C., Muhlrad, D., Donahue, J., Jacobson, A., and Parker, R. (1992) Analysis of chimeric mRNAs derived from the STE3 mRNA identifies multiple regions within yeast mRNAs that modulate mRNA decay. Nucleic Acids Res 20:5365-5373 |
|
Muhlrad, D., Hunter, R., and Parker, R. (1992) A rapid method for localized mutagenesis of yeast genes. Yeast 8:79-82 |
|