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RESEARCH	Nissan, T. and R. Parker.  Computtional analysis of miRNA-mediated repression of translation:  Implications for models of translaton initiation inhibition.  RNA (in press)
RESEARCH	She, M., Decker, C., Svergun, D.I., Round, A., Chen, N., Muhlrad, D., Parker, R., and H. Song (2008) Structural basis of Dcp2 recognition and activation by Dcp1. Molecular Cell 29:337-349
REVIEW	Beckham, C.J. and R. Parker (2008) P Bodies, Stress Granules, and Viral Life Cycles. Cell Host & Microbe 3:206-212
RESEARCH	Beckham, C.J., Hilliker, A., Cziko, A.-M., Noueiry, A., Ramaswami, M., and R. Parker. (2008) The DEAD-Box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies.  Molecular Biology of the Cell 19:984-993
RESEARCH	Pilkington, G., and R. Parker (2008) Pat1p contains distinct functional domains that promote P-body assembly and activation of decapping.Molecular and Cellular Biology 28:1298-1312
REVIEW	Buchan, J.R. and R. Parker. (2007) The Two Faces of miRNA. Science 318:1877-1878   (Summary)    (Full Text)
REVIEW	Doma, M.K. and R. Parker. (2007) Diversity, Principles and Consequences of RNA Quality Control in Eukaryotes. Cell 131:660-668
RESEARCH	Decker, C.J., Teixeira, D., and R. Parker (2007) Edc3p and a QN-rich domain of Lsm4p function in P-body Assembly in Saccharomyces cerevisiae. Journal of Cell Biology 179:437-449
RESEARCH	Beckham, C.J., Light, H.R., Nissan, T.A., Ahlquist, P., Parker, R., and A. Nouiery (2007) Interactions between Brome Mosaic Virus RNAs and Cytoplasmic Processing Bodies Journal of Virology 81:9759-9768
RESEARCH	Brengues, M. and R. Parker. (2007) Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae. Molecular Biology of the Cell 18:2592-2602
RESEARCH	Teixeira, D. and R. Parker. (2007) Analysis of P-body Assembly in Saccharomyces cerevisiae. Molecular Biology of the Cell 18:2274-2287
REVIEW	Sheth, U., and R. Parker. (2007) P-bodies and the control of mRNA translation and degradation. Molecular Cell 25:635-646
RESEARCH	Cheng, Z., Muhlrad, D., Lim, M.K., Parker, R. and H. Song (2007) Structural and functional insights into the human Upf1 helicase core. EMBO Journal 26:253-64
RESEARCH	Thompson, D. M., and R. Parker. (2007) Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae. MCB 27:92-101
REVIEW	Doma, M.K., and R. Parker. (2006). Revenge of the NRD: preferential degradation of nonfunctional eukaryotic rRNA. Developmental Cell 11:757-758
RESEARCH	Barbee, S.A., Estes, P.S., Cziko, A-M., Hillebrand, J., Luedeman, R.A., Coller, J.M., Johnson, N., Howlett, I.C., Geng, C., Ueda, R., Brand, A.H., Newbury, S.F., Wilhelm, J.E., Levine, R.B., Nakamura, A., Parker, R., and M. Ramaswami.  (2006)  Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies. Neuron 52:997-1009
REVIEW	Valencia-Sanchez, M., Liu, J., Hannon, G.J. and R. Parker.  (2006)  Control of translation and mRNA degradation by miRNAs and siRNAs.  Genes and Development 20:515-524
RESEARCH	Baker, K.E. and R. Parker. (2006) Conventional 3' end formation is not required for NMD substrate recognition in Saccharomyces cerevisiae RNA 12:1441-1445
RESEARCH	Sheth, U., and R. Parker. (2006) Targeting of Aberrant mRNAs to Cytoplasmic Processing Bodies.  Cell 125:1095-1109
RESEARCH	Segal, S.P., Dunckley, T.C., and R. Parker. Sbp1p promotes tranlsational repression and mRNA decapping in Saccharomyces cereivisiae.  MCB 26:5120-5130
RESEARCH	Doma, M.K., and R. Parker.  (2006)  Endonucleolytic cleavage of eukaryotic mRNAs with translation elongation stalls. Nature 440:561-564
REVIEW	Decker, C.J. and R. Parker (2006)  CAR-1 and trailer hitch:  Driving mRNP granule function at the ER?  Journal of Cell Biology Journal of Cell Biology 173:159-163
RESEARCH	Beliakova-Bethell, N., Beckham, C., Giddings Jr., T.H., Winey, M., Parker, R., and S. Sandmeyer.  (2006)  Virus-like particles of the Ty3 retrotransposon assemble in association with P-body components. RNA 12:94-101
RESEARCH	She, M., Decker, C.J., Chen, N., Tumati, S., Parker, R., and H. Song. (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe.Nature Structural & Molecular Biology (in press)
RESEARCH	Liu, J., Rivas, F.V., Wohlschlegel, J., Yates III, J.R., Parker, R., and G.J. Hannon. (2005) A role for the P-body component GW182 in microRNA function. Nature Cell Biology 7:1261-1266
RESEARCH	Coller, J. and R. Parker. (2005) General Translational Repression by Activators of mRNA Decapping. Cell 122:875-886
RESEARCH	Brengues, M., Teixeria, D. and R. Parker (2005) Movement of Eukaryotic mRNAs Between Polysomes and Cytoplasmic Processing Bodies. Science 310:486-489 Click here for access to complete article at Science
RESEARCH	Wilson, M., Meaux, S., Parker, R., and A. van Hoof. (2005).  Molecular mechanisms of [PSI+] induced phenotypic variation in yeast. Proc. Natl. Acad. Sci. USA 102:10244-10249
RESEARCH	Liu, J., Sanchez, M.A.V., Hannon, G.J., and R. Parker. (2005) MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nature Cell Biology 7:719-723
RESEARCH	Cheng, Z., Coller, J., Parker, R., and H. Song. (2005) Crystal structure and functional analysis of DEAD box helicase Dhh1p.  RNA 11:1258-1270
RESEARCH	Tharun, S., Muhlrad, D., Chowdhury, A., and R. Parker. (2005) Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection. Genetics, 170:33-46
RESEARCH	Teixeria, D., Sheth, U, Valencia-Sanchez, MA, Brengues, M., and R. Parker. (2005) Processing bodies require RNA for assembly and contain non-translating mRNAs. RNA 11:371-382
RESEARCH	Muhlrad, D. and R. Parker. (2005) The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p and Not5p. EMBO 24:1033-1045
RESEARCH	Chen, N., Walsh, M.A., Liu, Y., Parker, R., and H. Song. (2005) Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping.  Journal of Molecular Biology 347:707-718
RESEARCH	Cheng, Z., Liu, Y., Wang, C., Parker R., and H. Song.  (2004) Crystal structure of Ski8p, a WD-repeat protein with dual roles in mRNA metabolism and meiotic recomination.  Protein Science 13:2673-2684
RESEARCH	Baker, K.E., Coller, J.M., and R. Parker.  (2004)  Yeast Apq1p affects nucleocytoplasmic mRNA transport.  RNA 10:1352-1358
RESEARCH	Kshirsagar, M., and R. Parker, (2004) Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae.  Genetics 166:729-739
RESEARCH	She, M., Decker, C.J., Sundramurthy, K., Liu, Y., Chen, N., Parker, R. and H. Song. (2004) Crystal Structure of Dcp1p and Its Functional Implications in mRNA Decapping. Nature Structural and Molecular Biology 11:249-6
REVIEW	Baker, K.E., and R. Parker.  (2004)  Nonsense-mediated mRNA decay: terminating erroneous gene expression.  Current Opinion Cell Biology 16:293-9
REVIEW	Parker, R. and H. Song.  (2004) The Enzymes and Control of Eukaryotic mRNA Turnover. Nature Structural and Molecular Biology 11:121-127
REVIEW	Coller, J. and R. Parker.  (2004)  Eukaryotic mRNA decapping.  Annual Review of Biochmistry 73:861-890
RESEARCH	Hilleren, P.J., and R. Parker.  (2003)  Cytoplasmic Degradation of Splice Defective pre-mRNAs and Intermediates Molecular Cell 12:1453-1465
RESEARCH	Cao, D., and R. Parker.  (2003)  Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast.  Cell 113:533-545
RESEARCH	Sheth, U., and R. Parker.  (2003)  Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science  300:805-808
RESEARCH	Schwartz, D., Decker, C.J., and R. Parker. (2003) The Enhancer of Decapping Proteins, Edc1p and Edc2p, bind RNA and stimulate activity of the decapping enzyme. RNA 9:239-251
REVIEW	Decker, C.J. and R. Parker (2002) mRNA decay enzymes: Decappers conserved between yeast and mammals. Proc. Natl. Acad. Sci. USA 99:12512-12514
REVIEW	van Hoof, A., and R. Parker. (2002) Mammalian mRNA degradation: Beginning at the end. Current Biology 12:R285-R287
RESEARCH	Steiger, M., Carr-Schmid, A., Schwartz, D.C., Kiledjian, M., and R. Parker. (2002) Analysis of recombinant yeast decapping enzyme. RNA 9:231-238
REVIEW	Steiger, M., and R. Parker (2002) Analyzing mRNA Decay in Saccharomyces cerevisiae. Methods in Enzymology 351:648-660
REVIEW	Decker, C.J. and R. Parker (2002) mRNA decay enzymes: Decappers conserved between yeast and mammals. Proc. Natl. Acad. Sci. USA 99:12512-12514
RESEARCH	Frischmeyer, P.A., van Hoof, A., OíDonnell K., Guerrerio A.L., R. Parker and Dietz, H.C. (2002) An mRNA Surveillance Mechanism that Eliminates Transcripts Lacking Termination Codons. Science 295: 2258-2261
RESEARCH	van Hoof, A., Frischmeyer, P.A., Dietz, H.C., and R. Parker. (2002) Exosome-mediated recognition and degradation of mRNAs lacking a termination codon. Science 295: 2262-2264
RESEARCH	Tucker, M., Staples, R.R., Valencia-Sanchez, M.A., Muhlrad, D., and R. Parker. (2002) Ccr4p is the catalytic sub-unit of a Ccr4/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae. EMBO Journal 21:1427-1436
REVIEW	Wickens, M., Bernstein, D.S., Kimble, J., and R. Parker (2002) A PUF family portrait: 3íUTR regulation as a way of life. Trends in Genetics 18:150-157
RESEARCH	Hilleren, P., McCarthy, T., Rosbash, M., Parker, R., and Jensen, T.H. (2001) Quality control of mRNA 3í-end processing is linked to the nuclear exosome. Nature 413:538 - 542
RESEARCH	Coller, J.M., Tucker, M., Sheth, U., Valencia-Sanchez, M.A., and R. Parker. (2001) The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA 7:1717-27
RESEARCH	Tharun, S., and R. Parker. (2001) Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs. Molecular Cell 8:1075-83
RESEARCH	Cao, D., and R. Parker (2001) Computational modeling of eukaryotic mRNA turnover. RNA 7:1192-1212
RESEARCH	He, W. and R. Parker (2001) The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation. Genetics 158:1445-1455
RESEARCH	Tucker M., Valencia-Sanchez M.A., Staples R., Chen J., Denis C.L., and R. Parker (2001) The transcription factor associated proteins Ccr4 and Caf1 are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell 104:377-386
RESEARCH	Dunckley T., Tucker, M., and R. Parker (2001) Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 157:27-37
RESEARCH	Hilleren P., and R. Parker (2001) Defects in the mRNA export factors Rat7p, Gle1p, Mex67p and Rat8p cause hyperadenylation during 3'-end formation of nascent transcripts. RNA 7:753-64
REVIEW	Dunckley, T., and R. Parker (2001) Yeast mRNA Decapping Enzyme. Methods Enzymology 342:226-33
RESEARCH	Olivas, W. and R. Parker (2000) The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast EMBO Journal 19:6602-6611
RESEARCH	van Hoof, A., Staples, R. R., Baker, R. E. and R. Parker (2000)Function of the Ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Molecular and Cellular Biology 20:8230-8243
RESEARCH	Schwartz, D. and R. Parker (2000) mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E. Molecular and Cellular Biology 20:7933-7942
RESEARCH	Jacobs, J.S.J. and R. Parker (2000) Computational Identification of Cis-acting Elements Affecting Post-Transcriptional Control of Gene Expression in Saccharomyces cerevisiae. Nucleic Acids Research 28:1604-1617
RESEARCH	Tharun, S., He, W., Mayes, A.E., Lennertz, P., Beggs, J.D., and R. Parker (2000) Yeast Sm-like proteins function in mRNA decapping and decay. Nature 404:515-518
RESEARCH	van Hoof, A., Lennertz, P., and R. Parker. (2000) Three conserved members ofthe RNase D family have unique and overlapping functions inthe processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast. EMBO Journal 19: 1357-1365
RESEARCH	van Hoof, A., Lennertz, P. and R. Parker (2000) Yeast Exosome Mutants Accumulate 3'-Extended Polyadenylated Forms of U4 Small Nuclear RNA and Small Nucleolar RNAs. Molecular and Cellular Biology 20:441-452
REVIEW	Tucker, M. and R. Parker. (2000) Mechanisms and Control of mRNA Decapping in Saccharomyces cerevisiae. Annual Review of Biochemistry 69:571-95
REVIEW	He, W. and Parker R. (2000) Functions of Lsm proteins in mRNA degradation and splicing. Current Opinion in Cell Biology 12:346-350
RESEARCH	Muhlrad, D. and R. Parker (1999) Aberrant mRNAs with extended 3¹ UTRs are substrates for rapid degradation by mRNA surveillance. RNA 5:1299-1307
RESEARCH	Muhlrad, D. and R. Parker. (1999) Recognition of Yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: Implications for the control of mRNA decapping. Molecular Biology of the Cell 10: 3971-3978
RESEARCH	Dunckley, T. and R. Parker (1999) The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functinal MutT motif. EMBO Journal 18: 5411-5422
RESEARCH	Schwartz, D. and R. Parker (1999) Mutations in Translation Initiation Factors lead to increased rates of deadenylation and decapping of yeast mRNAs. Molecular and Cellular Biology 19:5247-56
RESEARCH	LaGrandeur, T. and R. Parker. (1999) The cis acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast includes the context of the translational short codon. RNA 5:420-33
REVIEW	Hilleren, P. and R. Parker. (1999) Mechanisms of mRNA Surveillance in Eukaryotes. Annual Review of Genetics 3:229-260
REVIEW	van Hoof, A. and R. Parker. (1999) The exosome: A proteasome for RNA? Cell 99:347-50
RESEARCH	Tharun, S. and R. Parker. (1999) Analysis of mutations in the yeast mRNA decapping enzyme. Genetics 151:1273-1285
REVIEW	Hilleren, P. and R. Parker. (1999) mRNA Surveillance in Eukaryotes: Kinetic Proofreading of Proper Translation Termination as assessed by mRNP Domain Organization? RNA 5:711-719
REVIEW	He, W. and R. Parker. (1999) Analysis of mRNA Decay Pathway in S. Cerevisiae. Methods 17:3-10
RESEARCH	LaGrandeur, T. E. and R. Parker. (1998) Isolation and Characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO Journal 17:1487-1496
RESEARCH	Anderson, J. S. J. and R. Parker. (1998) The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex. EMBO Journal 17:1497-1506
RESEARCH	Olivas, W. M., Muhlrad, D., and Parker, R. (1997). Analysis of the yeast genome: identification of new non-coding and small ORF-containing RNAs. Nucleic Acids Res 25:4619-4625
REVIEW	LaGrandeur, T. E. and R. Parker. (1997) mRNA decapping activities and their biological roles. Biochemie 78:1049-1055
RESEARCH	Caponigro, G., and Parker, R. (1996) mRNA turnover in yeast promoted by the MATalpha1 instability element. Nucleic Acids Res 24:4304-4312
RESEARCH	Hatfield, L., Beelman, C. A., Stevens, A., and Parker, R. (1996) Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol 16:5830-5838
REVIEW	Anderson, J. S., and Parker, R. (1996) RNA turnover: the helicase story unwinds. Curr Biol 6:780-782
REVIEW	Caponigro, G., and Parker, R. (1996) Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev 60:233-249
RESEARCH	Beelman, C. A., Stevens, A., Caponigro, G., LaGrandeur, T. E., Hatfield, L., Fortner, D., and Parker, R. (1996) An essential component of the decapping enzyme required for normal rates of mRNA decay in yeast. Nature 382:642-6
RESEARCH	Mandart, E., and Parker, R. (1995) Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAP1 genes on polyadenylation in vivo. Mol Cell Biol 15:6979-6986
REVIEW	Decker C. J., and Parker, R. (1995) Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts. Curr Opin Cell Biol 7:386-392
RESEARCH	Muhlrad D., Decker C. J., and Parker, R. (1995) Turnover mechanisms of the stable yeast PGK1 mRNA. Mol Cell Biol 15:2145-2156
REVIEW	Beelman, C. A. and Parker, R. (1995) Degradation of mRNA in eukaryotes. Cell 81:179-183
RESEARCH	Caponigro, G. and Parker, R. (1995) Multiple functions of the Poly(A) binding protein in mRNA decapping and deadenylation. Genes Dev 9:2421-2432
REVIEW	Decker C. J., and Parker, R. (1994) Mechanisms of mRNA degradation in eukaryotes. Trends Biochem Sci 19:336-340
RESEARCH	Beelman C. A., and Parker, R. (1994) Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem 269:9687-9692
RESEARCH	Muhlrad, D., and Parker, R. (1994) Premature translational termination triggers mRNA decapping. Nature 340:578-581
RESEARCH	Muhlrad, D., Decker, C. J., and Parker, R. (1994) Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5' to 3' degradation of the transcript. Genes Dev 8:855-866
RESEARCH	Decker, C. J., and Parker, R. (1993) A turnover pathway for stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev 7:1632-1643
RESEARCH	Parker, R. and P. Siliciano (1993) Evidence for a non-Watson Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron. Nature 361:660-662
RESEARCH	Caponigro, G., Muhlrad, D., and Parker, R. (1993) A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons. Mol Cell Biol 13:5141-5148
RESEARCH	Muhlrad, D., and Parker, R. (1992) Mutations affecting stability and deadenylation of the yeast MFA2 transcript. Genes Dev 6:2100-2111
RESEARCH	Heaton, B., Decker, C., Muhlrad, D., Donahue, J., Jacobson, A., and Parker, R. (1992) Analysis of chimeric mRNAs derived from the STE3 mRNA identifies multiple regions within yeast mRNAs that modulate mRNA decay. Nucleic Acids Res 20:5365-5373
RESEARCH	Muhlrad, D., Hunter, R., and Parker, R. (1992) A rapid method for localized mutagenesis of yeast genes. Yeast 8:79-82