spe-12

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Genetic Position I 2.53 (see genetic map in acedb)

Physical Location T02E1 (see cosmid info in acedb)

Sequence
Genomic DNA: Genbank Accession U57624

Protein: Genbank Accession 1373298

Graphical map and sequence in acedb

Cloned By Ward Lab

Homologies none

Mutant Alleles
hc76, hc149, hc150, hc151, hc152, hc155,

Strains available from CGC

Effect of Mutations Defective in receiving or processing the hermaphrodite spermiogenesis initiation signal: unmated hermaphrodites are self-sterile because their spermatids fail to undergo spermiogenesis; mated hermaphrodites are self- and outcross-fertile. Males are fertile. Spermatids from both males and hermaphrodites form spikes rather than pseudopods when exposed to pronase. Suppressible by spe-6 suppressor alleles.

References
L'Hernault SW, et al. Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans. Genetics. 1988 Oct 1; 120(2): 435-452.

Shakes DC, and S Ward Initiation of spermiogenesis in C. elegans: a pharmacological and genetic analysis. Dev Biol. 1989 Jul 1; 134(1): 189-200.

ACEDB/WormPD
ACEDB data
WormPD data

Genetic Position	I 2.53 (see genetic map in acedb)
Physical Location	T02E1 (see cosmid info in acedb)
Sequence	Genomic DNA: Genbank Accession U57624 Protein: Genbank Accession 1373298 Graphical map and sequence in acedb
Cloned By	Ward Lab
Homologies	none
Mutant Alleles	hc76, hc149, hc150, hc151, hc152, hc155, Strains available from CGC
Effect of Mutations	Defective in receiving or processing the hermaphrodite spermiogenesis initiation signal: unmated hermaphrodites are self-sterile because their spermatids fail to undergo spermiogenesis; mated hermaphrodites are self- and outcross-fertile. Males are fertile. Spermatids from both males and hermaphrodites form spikes rather than pseudopods when exposed to pronase. Suppressible by spe-6 suppressor alleles.
References	L'Hernault SW, et al. Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans. Genetics. 1988 Oct 1; 120(2): 435-452. Shakes DC, and S Ward Initiation of spermiogenesis in C. elegans: a pharmacological and genetic analysis. Dev Biol. 1989 Jul 1; 134(1): 189-200.
ACEDB/WormPD	ACEDB data WormPD data