spe-26

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Genetic Position  IV 4.58 (see genetic map in acedb)
Physical Location C26H10 (see cosmid info in acedb)
Sequence

Genomic DNA: Genbank Accession U20142

Protein: Genbank Accession 644842

Graphical map and sequence in acedb

Cloned By Ward Lab
Homologies Kelch/Scruin repeats. Possible actin-binding domain.
Mutant Alleles

it112ts, hc138ts, hc139ts, hc140ts, eb8

Strains available from CGC

Effect of Mutations Early spermatocyte arrest: mis-segregated chromosomes, mislocalized actin. No spermatids made. Lengthened lifespan.
References

Varkey, et al. The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin. Genes Dev. 1995 May 1; 9(9): 1074-1086.

Van Voorhies, Production of sperm reduces nematode lifespan. Nature. 1992 Dec 3; 360(6403): 456-458.

 

ACEDB/WormPD ACEDB data
WormPD data

  
http://www.mcb.arizona.edu/wardlab/spegenes/spe26.html
All Contents Copyright © 2000. All rights reserved.
Last Modified: July 12, 2000
Paul Muhlrad
pmuhlrad@u.arizona.edu