spe-4

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Genetic Position I 2.04

Physical Location ZK524

Sequence
Genomic DNA: Genbank Accession Z14067

mRNA: Genbank Accession Z14066

Protein: Accession 401112

Cloned By L'Hernault Lab

Homologies presenilin family of proteins associated with familial early onset Alzheimers disease (human S182 and C. elegans SEL-12)

Mutant Alleles
hc78 , hc81 , q347 (deletion null)

Strains available from CGC

Effect of Mutations Hermaphrodites and males produce primary spermatocytes that contain four haploid nuclei; males retain these spermatocytes while hermaphrodites resorb them when oogenesis begins; fibrous body-membranous organelle formation disrupted.

References
L'Hernault SW and PM Arduengo Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions. J Cell Biol. 1992 Oct 1; 119 (1): 55-68.

ACEDB/WormPD ACEDB data
WormPD data

http://www.mcb.arizona.edu/wardlab/spegenes/spe4.html
All Contents Copyright © 2000. All rights reserved.
Last Modified: July 12, 2000
Paul Muhlrad pmuhlrad@u.arizona.edu

Genetic Position	I 2.04
Physical Location	ZK524
Sequence	Genomic DNA: Genbank Accession Z14067 mRNA: Genbank Accession Z14066 Protein: Accession 401112
Cloned By	L'Hernault Lab
Homologies	presenilin family of proteins associated with familial early onset Alzheimers disease (human S182 and C. elegans SEL-12)
Mutant Alleles	hc78 , hc81 , q347 (deletion null) Strains available from CGC
Effect of Mutations	Hermaphrodites and males produce primary spermatocytes that contain four haploid nuclei; males retain these spermatocytes while hermaphrodites resorb them when oogenesis begins; fibrous body-membranous organelle formation disrupted.
References	L'Hernault SW and PM Arduengo Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions. J Cell Biol. 1992 Oct 1; 119 (1): 55-68.
ACEDB/WormPD	ACEDB data WormPD data