spe-6

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Genetic Position III 10.10 (see genetic map in acedb)

Physical Location

Sequence

Cloned By Not cloned

Homologies

Mutant Alleles
probable null alleles: hc49, hc92, hc143; hc146

"spermiogenesis suppressor" alleles (probably gain-of-function): hc163 & numerous others

Strains available from CGC

Effect of Mutations
Loss of function alleles: hermaphrodites and males produce primary spermatocytes that occasionally begin first meiotic division but do not differentiate further; MSP fails to assemble into fibrous bodies. Fail to complement an unlinked (chromosome IV) deficiency (eDf19)

"Suppressor" alleles: suppress spermiogenesis defect in spe-8, spe-12, spe-27, and spe-29 mutants; virgin males (and probably hermaphrodites) show precocious activation of spermatids.

References
Varkey, JP,et al. (1993) The Caenorhabditis elegans spe-6 gene is required for Major Sperm Protein Assembly and shows second site non-complementation with an unlinked deficiency. Genetics 133, 79-86.

ACEDB ACEDB data for spe-6

Genetic Position	III 10.10 (see genetic map in acedb)
Physical Location
Sequence
Cloned By	Not cloned
Homologies
Mutant Alleles	probable null alleles: hc49, hc92, hc143; hc146 "spermiogenesis suppressor" alleles (probably gain-of-function): hc163 & numerous others Strains available from CGC
Effect of Mutations	Loss of function alleles: hermaphrodites and males produce primary spermatocytes that occasionally begin first meiotic division but do not differentiate further; MSP fails to assemble into fibrous bodies. Fail to complement an unlinked (chromosome IV) deficiency (eDf19) "Suppressor" alleles: suppress spermiogenesis defect in spe-8, spe-12, spe-27, and spe-29 mutants; virgin males (and probably hermaphrodites) show precocious activation of spermatids.
References	Varkey, JP,et al. (1993) The Caenorhabditis elegans spe-6 gene is required for Major Sperm Protein Assembly and shows second site non-complementation with an unlinked deficiency. Genetics 133, 79-86.
ACEDB	ACEDB data for spe-6