Molecular & Cellular Biology

Revealing the secrets of nature & educating next generation of science innovators

Mechanisms of Disease

Mechanisms of Disease

Mechanisms of Disease

Understanding the molecular and cellular mechanisms of disease is one of the key goals of modern biomedical research. It is critical to dissecting the initiation, progression, and dissemination of human diseases, and is vital for the identification of appropriate therapeutic targets and the development of effective treatments.

Associated Faculty

The trafficking of macromolecules between different compartments is an essential process in all eukaryotic cells and is used to maintain cellular integrity, to interact with the extracellular environment, and to generally modulate various cellular activities. Numerous advances have been made in... Read More
Understanding the heterogeneous response of cancer cells to chemotherapy treatment Isogenic populations of cells often show very different responses to identical perturbations. For cancer cells this can manifest in a fractional response to chemotherapy treatment. We use quantitative fluorescence microscopy... Read More
Joyce Schroeder, PhD, holds research interests in the area of breast cancer progression and invasion. Transgenic mouse models of spontaneous carcinoma are used to understand the molecular mechanisms of primary tumor development and metastatic progression. Tumor growth and invasion is a complex process... Read More
What do we do? We study gene networks that control life and death decisions of cancer cells, and how they differ from normal cells. What is the goal of our research? We aim to better understand control mechanisms underlying various cell-fate decisions, and their connections to cancer development and aging,... Read More
1. Translational control in glia-neural stem cell interactions We have recently discovered a novel role for the RNA binding protein, FMRP, in neural stem cells exit from quiescence, a universal mechanism utilized by stem and progenitor cells across phyla. Furthermore, using tissue specific RNAi we found... Read More